Lesch-Nyhan syndrome is exceedingly rare in the general population, occurring in approximately one out of every 380,000 individuals (Genetics Home Reference, 2010).Pedigrees for LNS are very rare, but, since it is an X-linked recessive disease, it would be very similar to a hemophilia pedigree, shown below.
Where you can find out more*:
Genetics Home Reference. (2010). Lesch-Nyhan syndrome. U.S. National Library of Medicine. Retrieved November 3, 2010 from http://ghr.nlm.nih.gov/condition/lesch-nyhan-syndrome
Jinnah, H. A., et al. (2010). Attenuated variants of Lesch-Nyhan disease. Brain: A Journal of Neurology, 133(3), 671-689.
NOTE: the above primary source is viewable at http://brain.oxfordjournals.org/content/133/3/671.full
Jinnah, H. A. (2010). Lesch-Nyhan Syndrome. eMedicine Neurology. Retrieved November 3, 2010 from http://emedicine.medscape.com/article/1181356-overview
Kaneshiro, N. K. (2008). Lesch-Nyhan Syndrome. New York Times. Retrieved November 3, 2010 from http://health.nytimes.com/health/guides/disease/lesch-nyhan-syndrome/overview.html
Wrong Diagnosis. (2010). Lesch-Nyhan syndrome. Health Grades, Inc. Retrieved November 3, 2010 from http://www.wrongdiagnosis.com/l/lesch_nyhan_syndrome/intro.htm
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