Lesch-Nyhan syndrome is exceedingly rare in the general population, occurring in approximately one out of every 380,000 individuals (Genetics Home Reference, 2010).


A pedigree for hemophilia, another X-linked recessive disorder.

Pedigrees for LNS are very rare, but, since it is an X-linked recessive disease, it would be very similar to a hemophilia pedigree, shown below.

Where you can find out more*:

Genetics Home Reference. (2010). Lesch-Nyhan syndrome. U.S. National Library of Medicine. Retrieved November 3, 2010 from

Jinnah, H. A., et al. (2010). Attenuated variants of Lesch-Nyhan disease. Brain: A Journal of Neurology, 133(3), 671-689.

NOTE: the above primary source is viewable at

Jinnah, H. A. (2010). Lesch-Nyhan Syndrome. eMedicine Neurology. Retrieved November 3, 2010 from

Kaneshiro, N. K. (2008). Lesch-Nyhan Syndrome. New York Times. Retrieved November 3, 2010 from

Wrong Diagnosis. (2010). Lesch-Nyhan syndrome. Health Grades, Inc. Retrieved November 3, 2010 from

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