No treatment of Lesch-Nyhan syndrome itself currently exists. However, various existing medicines are used to treat the symptoms. For example, the gout medicine allopurinol is used to reduce uric levels in the body, which can reduce pain and spasticity in individuals suffering from from LNS. Other medicines including carbidopa/levodopa, diazepam, phenobarbital, or haloperidol are used to combat specific effects of the disease (Kaneshiro, 2008).

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